Texas A&M's Leticia Espinosa, a graduate student in chemistry, and Professor Ronald D. Macfarlane are using chemistry in new ways to study cardiovascular disease (CVD), which currently ranks as the No. 1 cause of death in the United States. Their efforts recently paid off in a prestigious way, meriting cover status in the January 15, 2006, edition of the peer-reviewed research journal Analytical Chemistry.

Their article, Method for Lipoprotein(a) Density Profiling by BiEDTA Differential Density Lipoprotein Ultracentrifugation, details their ongoing research on lipoprotein(a), a highly complex molecule that is a key emerging risk factor for development of the disease.

Despite many analytical challenges in using Lp(a) as a CVD marker -- its isolation, characterization and quantitation, to name a few -- the group has succeeded in developing a rapid method for its separation, purification and density measurement from serum using a procedure that is isoform independent.

Their research, conducted by Macfarlane's Laboratory for Cardiovascular Chemistry in conjunction with The Texas A&M University System Health Science Center and Scott & White Memorial Hospital, is partially funded by a grant from the National Institutes of Health.

The complete article is available via the journal's Web site at http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ac050962u


Contact: Shana K. Hutchins, (979) 862-1237 or shutchins@tamu.edu or Dr. Ronald Macfarlane, (979) 845-2021 or macfarlane@mail.chem.tamu.edu

Hutchins Shana

  • Cover Story

    The cover of Analytical Chemistry, Vol. 78, No. 2: January 15, 2006. The background is an image of a Coomassie Blue-stained SDS-PAGE gel that demonstrates the advantage of using ultracentrifugation for the purification of Lp(a) extracted from serum by wheat germ agglutinin (WGA).

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