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"Clinical data for MLN4924 is extremely promising, but cell studies indicate some forms of AML could be resistant. Consequently, it is highly desirable to explore compounds with the potential to prevent NAE interacting with NEDD8 in a different way, and that is the focus of the work CPRIT has decided to support. We are extremely grateful for this opportunity to explore this avenue of research."

Kevin Burgess, Texas A&M chemist
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